The goals of the project is to synthesize three different general nanocarriers to treat pancreatic

cancer, i.e.:

•  Synthesis of multifunctional amphiphilic triple stimuli-responsive hybrid miktoarm stars

composed of blocks of polypeptides such as poly(L-histidine) and poly(L-lysine) along with p

oly(ethylene oxide). The multifunctional polymer will have the inherent property to self-assemble

into vesicles and encapsulate a mixture of gemcitabine (hydrophilic drug) and everolimus

(hydrophobic drug) and deliver it selectively and efficiently into pancreatic cancer cells. The

nanocarriers will feature a pancreatic surface marker to target circulating tumor cells as well as

solid tumors.

• Synthesis of multifunctional triple stimuli-responsive injectable in situ forming polypeptidic

polymers that will form hydrogels and will release the hydrophilic drug gemcitabine directional only

towards the cancer cells. The hydrogels will be applied on solid tumors for a  long time sustainable

drug release.

• Synthesis of triple stimuli-responsive nanogels that will encapsulate and deliver selectively

hydrophilic and hydrophobic drugs of pancreatic cancer cells. The nanocarriers will feature a

pancreatic surface marker to target circulating tumor cells as well as solid tumors.

SYNTHESIS OF MULTIFUNCTIONAL AMPHIPHILIC HYBRID POLYPEPTIDES THAT FORM SMART DRUG AND GENE DELIVERY NANOCONSTRUCTS AGAINST PANCREATIC CANCER (PANNANOMED)